New: CML Expert Videos
ExploreWe have edited presentations from CML ONE 2021 on topics relevant to the Think Test Treat programme, creating short highlights videos, each 5–10 minutes in duration. Simona Soverini has also provided a dedicated video on the relevance of monitoring BCR-ABL1 kinetics versus key milestone measurements.
Dragana Milojkovic
Importance of consistent adherence to the ELN recommendations
Re-cap the recommendations for BCR-ABL1 monitoring and to what extent these are being adhered to in the UK and other countries. Find out more about potential barriers to BCR-ABL1 monitoring and the clinical impact of poor monitoring on patients
Simona Soverini
BCR-ABL1 transcript monitoring: Milestone measurements versus kinetics
Understand the dual importance of monitoring both molecular response at defined milestones and BCR-ABL1 transcript kinetics, including early kinetics in months 1–3 after TKI initiation, which can predict treatment outcomes and likelihood to achieve sustained TFR
Hugues de Lavallade
Prognostic value of low-level BCR-ABL1 mutations
Appreciate how NGS is now enabling us to detect low-level mutations and how this can provide an early indication of prognosis for each patient
CASE STUDIES: DETECTION OF LOW-LEVEL BCR-ABL1 MUTATIONS AND CLINICAL INTERVENTION
Visualise how screening for low-level mutations at 3, 6 and 12 months using NGS can help guide early clinical intervention, to potentially prevent the emergence of predominant mutant subclones and reduce the likelihood of disease progression
Thomas Lion
St Anna Children’s Cancer Research Institute
Relevance of BCR-ABL1 compound mutations
Acknowledge the challenge posed by compound mutations in BCR-ABL1 and how monitoring can guide selection of the appropriate TKI compound and dose
Predictive value of additional chromosomal abnormalities
Explore the role and importance of cytogenetic analysis today and how timely screening of additional chromosomal abnormalities can potentially limit their impact on disease course